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KMID : 0043319980210040478
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Archives of Pharmacal Research
1998 Volume.21 No. 4 p.478 ~ p.480
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Studies of Structure Activity Relationship of Flavonoids for the Anti-allergic Actions
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Cheong Ho
Ryu Shi-Yong
Oak Min-Ho
Cheon Seung-Hoon
Yoo Gyurng-Soo
Kim Kyeong-Man
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Abstract
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The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with values less than 10 .
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KEYWORD
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Allergy, Flavonoids, Degranulation, Hexosaminidase
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